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Product

Therapeutic Category

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COMBIPAR®

COMBIPAR is indicated for mild to moderate pain associated with inflammation.


Brand Name

COMBIPAR®


Packing

1 x 10 Tablets


Therapeutic Category

NSAIDs


Storage


adobe-pdf-logoProduct Insert(PIL)

adobe-pdf-logoPrescribing Information(SPC)


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Product Description

Product Overview


Composition:

Each tablet of COMBIPAR contains:
Ibuprofen ………………………. 400 mg
Paracetamol …………………. 500 mg

Each tablet of COMBIPAR KID contains:
Ibuprofen ……………………… 100 mg
Paracetamol ………………… 125 mg

Therapeutic Indications & Usage :

COMBIPAR is indicated for mild to moderate pain associated with inflammation.

Contraindications :

COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.

Precautions & Warnings :

COMBIPAR is to be advocated with caution in liver & kidney damage, elderly, patients requiring surgery, anemia, bronchial asthma, stomatitis, compromised cardiac function, heart failure, pre-existing edema, systemic lupus erythematosus.

Safe use of COMBIPAR in pregnancy and lactation has not been established. COMBIPAR should not be preferably coadministered with other NSAIDs, corticosteroids, hypoglycemics, digoxin, lithium, methotrexate, cyclosporine, coagulants & anticoagulants, bone marrow suppressants as well as probenecid.

Adverse Reactions :

The adverse reactions due to ibuprofen (in COMBIPAR) include cardiovascular manifestations (tachycardia, flushing & increase in blood pressure), GI complaints (particularly epigastric discomfort, ulceration & perforation), skin changes, hypersensitivity reactions, renal affections, aphthous stomatitis, gingival ulcerations, vision abnormalities, change in hearing, epistaxis, pancreatitis, hepatitis and hematological disturbances.

Side Effects of Paracetamol :

(in COMBIPAR) are rare, and usually mild. Skin rashes and other hypersensitivity reactions could occur, and, on rare occasions, paracetamol could cause hematological changes.

Drug Interaction :

Corticosteroids along with ibuprofen can enhance GI damage. Anticoagulants, heparin or thrombolytic agents are dangerous during COMBIPAR intake in view of ibuprofen’s potential to cause GI ulceration / bleeding. Ibuprofen (in COMBIPAR) can increase the hypoglycemic action of oral antidiabetics and insulin.

When given along with antihypertensives or agents with potential to suppress bone marrow (like some cephalosporins), ibuprofen can increase risk of edema and hematopoietic disturbances respectively. Ibuprofen (in COMBIPAR) can increase plasma concentrations of digoxin, cyclosporine, lithium and methotrexate.

Absorption of paracetamol from COMBIPAR is increased by concomitant metoclopramide, and such other agents. Probenecid can decrease it clearance and thereby increase paracetamol’s plasma half-life when given along with COMBIPAR.

Recommended Dosage & Administration :

Adults: 1 COMBIPAR Tab tid/qid, or as prescribed.

Children (ibuprofen: 20-30 mg/kg body
weight per day in divided doses;
paracetamol: 10-15 mg/kg body weight upto 4 times daily)

0.5-1 yr: ½ COMBIPAR KID Tab tid.
1-2 yrs: ½ COMBIPAR KID Tab tid / qid.
3-7 yrs: 1 COMBIPAR KID Tab tid / qid.
8-12 yrs: 2 COMBIPAR KID Tabs tid / qid.

COMBIPAR® – Taj Dearob Pharma|
COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.
COMBIPAR® – Taj Dearob Pharma|
COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.
COMBIPAR® – Taj Dearob Pharma|
COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.
COMBIPAR® – Taj Dearob Pharma| COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.
COMBIPAR® – Taj Dearob Pharma| COMBIPAR is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.

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Taj Dearob Pharmaceuticals is an Ghana based pharmaceutical company that markets a broad range of innovative therapeutic medicines including UK Generics, high-end Oncology products, more info.