Not Just Receptors – Taj Accura Pharmaceuticals’ Oncology Target DNA

Many chemotherapeutics work to prevent cell division and thus suppress overactive cells. Three products that Taj Accura Pharmaceuticals provide, interfere with the four key nucleotides, which are divided into the subcategory of purines or pyrimidines based on their chemical structure that make up DNA, necessary for cell division as an information database for protein synthesis in the cell.

Mercaptopurine is indicated for the treatment of acute leukaemia.

Fludarabine and Thioguanine act as purine antagonists, which interfere with the nucleotides adenine and guanine preventing DNA production. They are recommended in the treatment of leukemia from the British National Formulary (February 2015), with Thioguanine being a preferential option to Mercaptopurine as it is less likely to cause gastrointestinal upset.

Fludarabine has been commended for its tolerance within patients, and is indicated in NICE guidelines as a second line agent via oral administration in the treatment of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone), CAP (cyclophosphamide, doxorubicin and prednisolone) or CVP (cyclophosphamide, vincristine and prednisolone) chemotherapeutic regimens . In a well-established clinical study published in the Journal of Clinical Oncology , fludarabine has also been indicated in the treatment of chronic lymphocytic leukemia alongside a regimen of rituximab and cyclophosphamide. In stage III and IV patients, the regimen which began after diagnosis showed a complete response rate of 70 %, a key diagnostic entity, which confirms disappearance of the disease via flow cytometry. A predicted 69 % failure free rate after four years of treatment has been accredited to Rituximab capability at increasing the toxicity of both fludarabine and cyclophosphamide.

Cytarabine on the other hand is a pyrimidine antagonist, which distorts the use of thymine and cytosine in DNA replication, which is in the same class as the widely used 5-fluorouracil. Cytarabine has a specialised monopolised role in the treatment of consolidation chemotherapy in acute myeloid leukemia, which is defined as treatment post remission to prevent relapse and kill any previously existent leukemia following initial chemotherapy regimens. One particular paper explored the comparison of treatment in older AML patients with cycles of high dose Cytarabine as opposed to more traditionally seen drugs, whereby there is no official regimen of consolidation treatment. Cytarabine excelled significantly in terms of disease free survival as well as showing some advantage to affected patients.

Conclusion:

Cytarabine, Fludarabine and Thioguanine are available to an international market from Taj Accura Pharmaceuticals. We pride ourselves with a wide range of oncology products, which can be made in compliance with relevant regulations and pharmacopoeial specifications. Fludarabine is available as either 10 mg tablets or injectable form, in 25 mg/mL, 50 mg/mL or 50 mg/2 mL vials. Cytarabine is available as an injectable form in 20 mg/1 mL, 50 mg/5 mL, 100 mg/5 mL, 500 mg/5 mL, 1g/50 mL doses. Thioguanine comes in 40 mg tablets, which is optimal for patient acceptability and adherence while also reducing healthcare costs associated with specialist healthcare professional administration.

Not Just Receptors – Taj Accura Pharmaceuticals’ Oncology Target DNA – Taj Dearob Pharma | Many chemotherapeutics work to prevent cell division and thus suppress overactive cells. Three products that Taj Accura Pharmaceuticals provide, interfere with the four key nucleotides, which are divided into the subcategory of purines or pyrimidines based on their chemical structure that make up DNA, necessary for cell division as an information database for protein synthesis in the cell.
Not Just Receptors – Taj Accura Pharmaceuticals’ Oncology Target DNA – Taj Dearob Pharma | Many chemotherapeutics work to prevent cell division and thus suppress overactive cells. Three products that Taj Accura Pharmaceuticals provide, interfere with the four key nucleotides, which are divided into the subcategory of purines or pyrimidines based on their chemical structure that make up DNA, necessary for cell division as an information database for protein synthesis in the cell.